Accuracy of Blood Cell Analyzer: How the Physiological State, Analyzer and Reagents Affect

In addition to many pathological conditions that can cause changes in blood cell counts, many physiological states can also cause changes in various parameters. For example, the total number of white blood cells in pregnant women and newborns is significantly increased. Heat and cold often cause a transient increase in total leukocyte count. In heavy smokers, the hemoglobin level can increase significantly due to increased carbon monoxide in the blood. The total number of leukocytes also varies at different times of the day.

The aspiration needle, liquid tubing and counting cell should be thoroughly cleaned regularly with enzyme cleaner or 5% sodium hypochlorite. This is to prevent protein buildup. If there is protein buildup around the counting cell, it can affect the cell volume measurement and cause an increase in MCV. If the hemoglobin colorimetric pool is dirty, it can affect the hemoglobin quantitative results.